1-(2-Chloroethoxy)-4-nitrobenzene

Basic Information

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CAS Number

3383-72-0

Molecular Formula

C8H8ClNO3

Molecular Weight

201.61 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Fine Chemicals Dyes and Pigments Organic Dyes

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

57.0 to 61.0 deg-C

Boiling Point

206°C/25mmHg

SMILES

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C1=CC(=CC=C1[N+](=O)[O-])OCCCl

InChI

InChI=1S/C8H8ClNO3/c9-5-6-13-8-3-1-7(2-4-8)10(11)12/h1-4H,5-6H2

InChIKey

OBCFOPGCTNULTG-UHFFFAOYSA-N

LogP

2.73560

Complexity

163

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

DTXSID10377513
SY031416
2-[4-nitrophenoxy]ethyl chloride
4-(2-Chloroethoxy)nitrobenzene
FT-0634813
SCHEMBL1735227
C3523
2-chloroethyl 4-nitrophenyl ether
3383-72-0
OBCFOPGCTNULTG-UHFFFAOYSA-N
Benzene, 1-(2-chloroethoxy)-4-nitro-
2-CHLOROETHYL-4-NITROPHENYL ETHER
4-Nitrophenyl 2-chloroethyl ether
1-(2-chloro-ethoxy)-4-nitro-benzene
4-nitro-(2-chloroethoxy)benzene
AKOS005073503
1-(2-Chloroethoxy)-4-nitrobenzene
2-(4-Nitrophenoxy)ethyl chloride
1-(2-chloroethyloxy)-4-nitro-benzene
4-Nitro-1-(2-chloroethoxy)benzene
MFCD00674505
beta-Chloro-4-nitrophenethole
AM83076
MS-5009
J-502977
2-(4-Nitrophenoxy)ethylchlorid
1(2-chloroethoxy)-4-nitrobenzene
A821955
NS00004043
CS-0035627
(2-chloro-ethyl)-(4-nitro-phenyl)-ether

MDL Number

MFCD00674505

Customs Code

2909309090

FAQ

What are the physical and chemical properties of 1-(2-Chloroethoxy)-4-nitrobenzene (CAS: 3383-72-0)?

1-(2-Chloroethoxy)-4-nitrobenzene (CAS: 3383-72-0) is a crystalline solid with a molecular weight of approximately 239.01 g/mol. It has a low solubility in water but is more soluble in organic solvents such as ethanol and acetone. Chemically, it is known for its reactivity towards nucleophiles and reducing agents. It is an important intermediate in organic synthesis and pharmaceuticals.

How is 1-(2-Chloroethoxy)-4-nitrobenzene (CAS: 3383-72-0) typically synthesized?

1-(2-Chloroethoxy)-4-nitrobenzene (CAS: 3383-72-0) can be synthesized via the Grignard reaction, where 2-chloroethanol reacts with 4-nitrobenzyl bromide in the presence of a Grignard reagent. This method provides good yield and control over the reaction conditions. Other synthetic routes involve the use of diazonium salts and subsequent coupling reactions.

What industries use 1-(2-Chloroethoxy)-4-nitrobenzene (CAS: 3383-72-0)?

1-(2-Chloroethoxy)-4-nitrobenzene (CAS: 3383-72-0) is primarily used in the pharmaceutical industry as a precursor for the synthesis of various drugs. It also finds applications in the chemical industry, particularly in the production of dyes and other organic compounds. Its reactivity makes it valuable in both research and manufacturing processes.

What precautions should be taken when handling 1-(2-Chloroethoxy)-4-nitrobenzene (CAS: 3383-72-0)?

When handling 1-(2-Chloroethoxy)-4-nitrobenzene (CAS: 3383-72-0), it is essential to use appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or fume hood to minimize exposure. Spills should be cleaned up using appropriate safety measures, and the material safety data sheet (MSDS) should be consulted for detailed information on safety and handling.