H-Val-Ala-OH | CAS No. 27493-61-4

H-Val-Ala-OH

Basic Information

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CAS Number

27493-61-4

Molecular Formula

C8H16N2O3

Molecular Weight

188.23 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Physical Properties

Melting Point

257-258 ºC

Boiling Point

401.8°C at 760 mmHg

SMILES

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CC(C)C(C(=O)NC(C)C(=O)O)N

InChI

InChI=1S/C8H16N2O3/c1-4(2)6(9)7(11)10-5(3)8(12)13/h4-6H,9H2,1-3H3,(H,10,11)(H,12,13)/t5-,6-/m0/s1

InChIKey

HSRXSKHRSXRCFC-WDSKDSINSA-N

LogP

-0.44099999999999967

Topological Polar Surface Area

92.41999999999999 Å²

Hydrogen Bond Donor/Acceptor

4 / 5

Complexity

204

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

DTXSID60426328
HY-W007035
L-Val-L-Ala
CHEMBL55523
Valyl-alanineValyl-alanine
Val-Ala
(S)-2-((S)-2-Amino-3-methylbutanamido)propanoic acid
Valine Alanine dipeptide
27493-61-4
Valyl-Alanine
A876911
Val-Ala-OH
J-016790
Valylalanine
Q27145065
VA dipeptide
H-Val-Ala-OH, AldrichCPR
SCHEMBL1711406
CS-W007035
MFCD00020397
Alanine, N-L-valyl-
Valine-Alanine dipeptide
BP-27957
HSRXSKHRSXRCFC-WDSKDSINSA-N
CHEBI:75008
(S)-2-((S)-2-Amino-3-methylbutanamido)propanoic acid (H-L-Val-L-Ala-OH)
L-valyl-L-alanine
(2S)-2-[[(2S)-2-amino-3-methylbutanoyl]amino]propanoic acid
V-A Dipeptide
H-VAL-ALA-OH
AKOS010420475

MDL Number

MFCD00020397

Customs Code

2924199090

FAQ

What are the physical and chemical properties of H-Val-Ala-OH (CAS: 27493-61-4)?

H-Val-Ala-OH (CAS: 27493-61-4) is a crystalline compound with a molecular weight of approximately 161.19 g/mol. It is sparingly soluble in water and slightly more soluble in organic solvents. The compound has a basic pH and shows moderate reactivity towards acidic conditions. It is stable under normal storage conditions but should be protected from strong acids and bases.

How is H-Val-Ala-OH (CAS: 27493-61-4) typically synthesized?

H-Val-Ala-OH (CAS: 27493-61-4) is typically synthesized via a solid-phase peptide synthesis method. The process involves the sequential addition of amino acids (Val and Ala) to a growing peptide chain using an Fmoc (9-fluorenylmethyl carbamate) protecting group. Commonly used catalysts include HATU (O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate) and DIPEA (N,N-diisopropylethylamine). The yield is generally high, around 80-90%, with good selectivity.

What industries use H-Val-Ala-OH (CAS: 27493-61-4)?

H-Val-Ala-OH (CAS: 27493-61-4) is primarily used in the pharmaceutical industry for the development of bioactive peptides and as a research tool. It is also utilized in the polymer industry for the synthesis of biodegradable polymers and in the sensor industry for the creation of biosensors. Additionally, it is used in semiconductor applications for the fabrication of thin films.

What precautions should be taken when handling H-Val-Ala-OH (CAS: 27493-61-4)?

When handling H-Val-Ala-OH (CAS: 27493-61-4), it is essential to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Ensure that the work is conducted in a well-ventilated area or with the use of a fume hood. Spills should be cleaned up immediately using a suitable absorbent material and disposed of according to local regulations. Always consult the Safety Data Sheet (SDS) for detailed safety information and emergency procedures.