2-Thiophenecarbohydrazide

Basic Information

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CAS Number

2361-27-5

Molecular Formula

C5H6N2OS

Molecular Weight

142.18 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Water Treatment Chemicals Coagulants and Flocculants Inorganic Coagulants

Basic Physical Properties

Melting Point

137.0 to 140.0 deg-C

Boiling Point

260°Cat760mmHg

Flash Point

117.8°C

Refractive Index

1.6430 (estimate)

SMILES

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C1=CSC(=C1)C(=O)NN

InChI

InChI=1S/C5H6N2OS/c6-7-5(8)4-2-1-3-9-4/h1-3H,6H2,(H,7,8)

InChIKey

SOGBOGBTIKMGFS-UHFFFAOYSA-N

LogP

0.35159999999999975

Topological Polar Surface Area

55.12 Å²

Hydrogen Bond Donor/Acceptor

3 / 3

Complexity

118

Safety Information

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GHS Hazard Pictograms

H315

H319

H335

Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

SOGBOGBTIKMGFS-UHFFFAOYSA-
FT-0634215
NSC 653
2-Thiophenecarbohydrazide #
2-Thiophenecarboxylic acid hydrazide
2-Thiophenecarboxylic hydrazide
2-Thienyl hydrazide
2-thiophencarboxylic acid hydrazide
F10320
W-107392
NSC-653
W4J3WEF93N
AM9858
CS-W018291
UNII-W4J3WEF93N
NSC-120045
HMS1722A21
NSC653
thenohydrazide
NSC120045
MFCD00005435
Thiophene-2-carboxylic acid hydrazide
Thiophene-2-carbohydrazide
A816801
SCHEMBL355263
2361-27-5
AKOS000200290
2-Thienylcarboxylic acid hydrazide
Z56974792
F3146-2497
2-thiophene carboxylic acid hydrazide

MDL Number

MFCD00005435

Customs Code

2934999090

FAQ

What are the physical and chemical properties of 2-Thiophenecarbohydrazide (CAS: 2361-27-5)?

2-Thiophenecarbohydrazide is a crystalline solid with a molecular weight of approximately 181.19 g/mol. It has a solubility of about 1.5 g/100 mL in water and is sparingly soluble in organic solvents. It is known for its reactivity towards electrophiles and can undergo amidation and reduction reactions.

How is 2-Thiophenecarbohydrazide (CAS: 2361-27-5) typically synthesized?

2-Thiophenecarbohydrazide is typically synthesized by reacting thiophene-2-carboxaldehyde with hydrazine hydrate. This synthesis involves the condensation of the aldehyde with hydrazine followed by the removal of water to form the final product. The reaction is carried out in a suitable solvent such as acetic acid, and the yield is generally around 70-80%.

What industries use 2-Thiophenecarbohydrazide (CAS: 2361-27-5)?

2-Thiophenecarbohydrazide is primarily used in the pharmaceutical industry for the synthesis of certain drugs. It also finds applications in the polymer industry for the preparation of functional polymers, and in the sensor and semiconductor industries for its reactivity and electronic properties.

What precautions should be taken when handling 2-Thiophenecarbohydrazide (CAS: 2361-27-5)?

When handling 2-Thiophenecarbohydrazide, wear appropriate personal protective equipment (PPE) including gloves, goggles, and a lab coat. Ensure the use of a fume hood during handling to prevent inhalation of the compound. Spills should be cleaned up using appropriate solvents, and the area should be well ventilated. Always refer to the Safety Data Sheet (SDS) for detailed handling and emergency procedures.