2-Thiophenecarbohydrazide(CAS: 2361-27-5)

2-Thiophenecarbohydrazide is a crystalline solid with a molecular weight of approximately 181.19 g/mol. It has a solubility of about 1.5 g/100 mL in water and is sparingly soluble in organic solvents. It is known for its reactivity towards electrophiles and can undergo amidation and reduction reactions.

2-Thiophenecarbohydrazide is typically synthesized by reacting thiophene-2-carboxaldehyde with hydrazine hydrate. This synthesis involves the condensation of the aldehyde with hydrazine followed by the removal of water to form the final product. The reaction is carried out in a suitable solvent such as acetic acid, and the yield is generally around 70-80%.

2-Thiophenecarbohydrazide is primarily used in the pharmaceutical industry for the synthesis of certain drugs. It also finds applications in the polymer industry for the preparation of functional polymers, and in the sensor and semiconductor industries for its reactivity and electronic properties.

When handling 2-Thiophenecarbohydrazide, wear appropriate personal protective equipment (PPE) including gloves, goggles, and a lab coat. Ensure the use of a fume hood during handling to prevent inhalation of the compound. Spills should be cleaned up using appropriate solvents, and the area should be well ventilated. Always refer to the Safety Data Sheet (SDS) for detailed handling and emergency procedures.