2-Chloro-4-methoxypyrimidine

Basic Information

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CAS Number

22536-63-6

Molecular Formula

C5H5ClN2O

Molecular Weight

144.56 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Physical State

White to Yellow Solid

Melting Point

54-57 °C

Boiling Point

268.8℃ at 760 mmHg

Density

1.292

Refractive Index

1.52

SMILES

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COC1=NC(=NC=C1)Cl

InChI

InChI=1S/C5H5ClN2O/c1-9-4-2-3-7-5(6)8-4/h2-3H,1H3

InChIKey

BDXYNMVQMBCTDB-UHFFFAOYSA-N

LogP

1.1385999999999998

Topological Polar Surface Area

35.010000000000005 Å²

Hydrogen Bond Donor/Acceptor

0 / 3

Complexity

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

2-chloro-4-(methyloxy)pyrimidine
4-methoxy-2-chloropyrimidine
22536-63-6
CS-W002506
SY015694
AKOS001012384
2-Chloro-4-methoxypyrimidine, 98%
STR07516
MFCD00194055
J-508759
DTXSID40343307
Pyrimidine, 2-chloro-4-methoxy-
Z56767615
EN300-15259
2-chloro -4-methoxypyrimidine
2-chloro4-methoxypyrimidine
A15388
2-Chloro-4-methoxy-pyrimidine
AM20090223
2-Chloro-4-methoxypyrimidine
F0704-0011
SCHEMBL61299
FT-0647012
CL1909
AC-23210
SB57749
BCP27244
2-Chlor-4-methoxy-pyrimidin
2-chloro-4-methoy pyrimidine
2-chloro-6-methoxypyrimidine
BDXYNMVQMBCTDB-UHFFFAOYSA-N

MDL Number

MFCD00194055

Customs Code

2933599090

FAQ

What are the physical and chemical properties of 2-Chloro-4-methoxypyrimidine (CAS: 22536-63-6)?

2-Chloro-4-methoxypyrimidine is a solid with a crystalline form. Its molecular weight is approximately 167.01 g/mol. It has a low solubility in water but is more soluble in organic solvents like methanol and acetone. This compound exhibits moderate reactivity, particularly towards nucleophiles. It is commonly stored in a sealed container away from moisture and heat.

How is 2-Chloro-4-methoxypyrimidine (CAS: 22536-63-6) typically synthesized?

2-Chloro-4-methoxypyrimidine is typically synthesized via a nucleophilic substitution reaction. The reaction involves the substitution of a chlorine atom in 4-chloropyrimidine with a methoxy group. This can be achieved using methanol in the presence of a base such as sodium methoxide. The reaction is carried out in an inert atmosphere to prevent side reactions.

What industries use 2-Chloro-4-methoxypyrimidine (CAS: 22536-63-6)?

2-Chloro-4-methoxypyrimidine is used in the pharmaceutical industry as an intermediate in the synthesis of various drugs. It is also used in the chemical industry for the production of pyrimidine derivatives, which can be used in polymers, sensors, and semiconductors.

What precautions should be taken when handling 2-Chloro-4-methoxypyrimidine (CAS: 22536-63-6)?

When handling 2-Chloro-4-methoxypyrimidine, it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a fume hood to minimize inhalation risks. Spills should be cleaned up carefully using appropriate absorbents and disposing of waste according to local regulations. Always refer to the Safety Data Sheet (SDS) for specific handling instructions.