2-Chloro-4-methoxypyrimidine(CAS: 22536-63-6)

2-Chloro-4-methoxypyrimidine is a solid with a crystalline form. Its molecular weight is approximately 167.01 g/mol. It has a low solubility in water but is more soluble in organic solvents like methanol and acetone. This compound exhibits moderate reactivity, particularly towards nucleophiles. It is commonly stored in a sealed container away from moisture and heat.

2-Chloro-4-methoxypyrimidine is typically synthesized via a nucleophilic substitution reaction. The reaction involves the substitution of a chlorine atom in 4-chloropyrimidine with a methoxy group. This can be achieved using methanol in the presence of a base such as sodium methoxide. The reaction is carried out in an inert atmosphere to prevent side reactions.

2-Chloro-4-methoxypyrimidine is used in the pharmaceutical industry as an intermediate in the synthesis of various drugs. It is also used in the chemical industry for the production of pyrimidine derivatives, which can be used in polymers, sensors, and semiconductors.

When handling 2-Chloro-4-methoxypyrimidine, it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a fume hood to minimize inhalation risks. Spills should be cleaned up carefully using appropriate absorbents and disposing of waste according to local regulations. Always refer to the Safety Data Sheet (SDS) for specific handling instructions.