Ethyl 6-formyl-2-pyridinecarboxylate

Basic Information

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CAS Number

21908-10-1

Molecular Formula

C9H9NO3

Molecular Weight

179.17 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Aldehydes

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Basic Physical Properties

Physical State

Pale-yellow to Yellow-brown Solid

SMILES

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CCOC(=O)c1cccc(C=O)n1

InChI

InChI=1S/C9H9NO3/c1-2-13-9(12)8-5-3-4-7(6-11)10-8/h3-6H,2H2,1H3

InChIKey

PILDWRGFGKVUSE-UHFFFAOYSA-N

LogP

1.0708

Topological Polar Surface Area

56.260000000000005 Å²

Hydrogen Bond Donor/Acceptor

0 / 4

Safety Information

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GHS Hazard Pictograms

H302

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

Synonyms & References

English

6-formyl-2-Pyridinecarboxylic acid ethyl ester
2-Pyridinecarboxylic acid, 6-formyl-, ethyl ester
Ethyl 6-formylpicolinate
Ethyl 6-formylpyridine-2-carboxylate
2-Formyl-pyridin-carbonsaeure-(6)-ethylester
6-formyl-2-picolinic acid ethyl ester
6-Formyl-pyridine-2-carboxylic acid ethyl ester
ethyl 6-formyl-2-pyridinecarboxylate

MDL Number

MFCD11501347

Customs Code

2933399090

FAQ

What are the physical and chemical properties of Ethyl 6-formyl-2-pyridinecarboxylate (CAS: 21908-10-1)?

Ethyl 6-formyl-2-pyridinecarboxylate (CAS: 21908-10-1) is a crystalline compound with a molecular weight of approximately 180.18 g/mol. It has a low solubility in water but is soluble in common organic solvents like ethanol and acetone. The compound exhibits moderate reactivity, particularly under acidic conditions. It can undergo nucleophilic substitution and condensation reactions.

How is Ethyl 6-formyl-2-pyridinecarboxylate (CAS: 21908-10-1) typically synthesized?

Ethyl 6-formyl-2-pyridinecarboxylate (CAS: 21908-10-1) can be synthesized via the condensation of formylacetate with 2-pyridinecarboxaldehyde. This reaction typically involves the use of a base like sodium hydroxide and is carried out in an organic solvent such as ethanol. The yield is generally around 75-85%, depending on the purity of the reactants and the reaction conditions.

What industries use Ethyl 6-formyl-2-pyridinecarboxylate (CAS: 21908-10-1)?

Ethyl 6-formyl-2-pyridinecarboxylate (CAS: 21908-10-1) is primarily used in the pharmaceutical industry for the synthesis of certain drug intermediates. It also has applications in the polymer industry for the modification of polymer properties and in the semiconductor industry for the production of organic semiconductors.

What precautions should be taken when handling Ethyl 6-formyl-2-pyridinecarboxylate (CAS: 21908-10-1)?

When handling Ethyl 6-formyl-2-pyridinecarboxylate (CAS: 21908-10-1), it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be performed in a well-ventilated area or a fume hood to minimize inhalation risk. Spills should be cleaned up by wearing appropriate PPE, and the area should be thoroughly ventilated. Refer to the Safety Data Sheet (SDS) for more detailed information on handling and safety measures.