2-Methoxybenzoyl chloride

Basic Information

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CAS Number

21615-34-9

Molecular Formula

C8H7ClO2

Molecular Weight

170.59 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Fine Chemicals Dyes and Pigments Organic Dyes

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Boiling Point

140°C/26mmHg

Refractive Index

n20/D 1.572(lit.)

SMILES

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COC1=CC=CC=C1C(=O)Cl

InChI

InChI=1S/C8H7ClO2/c1-11-7-5-3-2-4-6(7)8(9)10/h2-5H,1H3

InChIKey

RZNHSEZOLFEFGB-UHFFFAOYSA-N

LogP

2.0742000000000003

Topological Polar Surface Area

26.3 Å²

Hydrogen Bond Donor/Acceptor

0 / 2

Complexity

147

Safety Information

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Hazard Statement

H227 Combustible liquid
Flammable liquids

H290 May be corrosive to metals
Corrosive to Metals

H314 Causes severe skin burns and eye damage
Skin corrosion/irritation

Hazard Class

Class 8 Class 8

Sensitiveness

Moisture Sensitive

Synonyms & References

English

EINECS 215-088-8
2-anisoyl chloride
Benzoyl chloride, methoxy-
2-Methoxybenzoyl chloride, 97%
NSC 174039
EN300-65599
UNII-D2N62KD6V8
2-(methyloxy)benzoyl chloride
MFCD00000664
2-methoxybenzoic chloride
D2N62KD6V8
AMY37150
AKOS009157079
RZNHSEZOLFEFGB-UHFFFAOYSA-
M0108
DH3HW7ZFD8
2-Methoxy benzoyl chloride
UNII-DH3HW7ZFD8
NS00045010
W-107539
EINECS 244-477-5
o-Methoxybenzoyl chloride
Benzoyl chloride, 2-methoxy-
Methoxybenzoyl chloride
2-Methoxybenzoyl chloride
2-METHOXYBENZOYLCHLORIDE
2-methoxy-benzoyl chloride
21615-34-9
SCHEMBL431
1300-64-7
2-methoxy-1-benzenecarbonyl chloride

MDL Number

MFCD00000664

Customs Code

29189090

FAQ

What are the physical and chemical properties of 2-Methoxybenzoyl chloride (CAS: 21615-34-9)?

2-Methoxybenzoyl chloride is a colorless to light yellow liquid with a molecular weight of 201.17 g/mol. It has a pKa of 2.8 and is soluble in common organic solvents like ethanol and acetone. It is highly reactive, particularly towards nucleophilic substitution reactions and is prone to hydrolysis to form methoxybenzoic acid.

How is 2-Methoxybenzoyl chloride (CAS: 21615-34-9) typically synthesized?

2-Methoxybenzoyl chloride is synthesized via the chlorination of 2-methoxybenzoyl fluoride. This process often involves the use of a Lewis acid catalyst such as aluminum chloride. The reaction is highly exothermic, and careful temperature control is necessary to achieve high yield and selectivity.

What industries use 2-Methoxybenzoyl chloride (CAS: 21615-34-9)?

2-Methoxybenzoyl chloride is used in various industries, particularly in the pharmaceutical industry for the synthesis of active pharmaceutical ingredients. It is also utilized in the production of chemical intermediates for polymers and in the development of sensors and semiconductors due to its reactivity and functionality.

What precautions should be taken when handling 2-Methoxybenzoyl chloride (CAS: 21615-34-9)?

When handling 2-Methoxybenzoyl chloride, it is essential to use appropriate personal protective equipment (PPE), including gloves, safety glasses, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood. Spills should be handled with appropriate absorbents and disposed of according to local regulations. Always refer to the Material Safety Data Sheet (MSDS) for detailed safety information.