2-Methoxybenzoyl chloride(CAS: 21615-34-9)

2-Methoxybenzoyl chloride is a colorless to light yellow liquid with a molecular weight of 201.17 g/mol. It has a pKa of 2.8 and is soluble in common organic solvents like ethanol and acetone. It is highly reactive, particularly towards nucleophilic substitution reactions and is prone to hydrolysis to form methoxybenzoic acid.

2-Methoxybenzoyl chloride is synthesized via the chlorination of 2-methoxybenzoyl fluoride. This process often involves the use of a Lewis acid catalyst such as aluminum chloride. The reaction is highly exothermic, and careful temperature control is necessary to achieve high yield and selectivity.

2-Methoxybenzoyl chloride is used in various industries, particularly in the pharmaceutical industry for the synthesis of active pharmaceutical ingredients. It is also utilized in the production of chemical intermediates for polymers and in the development of sensors and semiconductors due to its reactivity and functionality.

When handling 2-Methoxybenzoyl chloride, it is essential to use appropriate personal protective equipment (PPE), including gloves, safety glasses, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood. Spills should be handled with appropriate absorbents and disposed of according to local regulations. Always refer to the Material Safety Data Sheet (MSDS) for detailed safety information.