5-Indolinol | CAS No. 172078-33-0

5-Indolinol

Basic Information

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CAS Number

172078-33-0

Molecular Formula

C8H9NO

Molecular Weight

135.17 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Boiling Point

322.2°C at 760 mmHg

SMILES

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C1CNC2=C1C=C(C=C2)O

InChI

InChI=1S/C8H9NO/c10-7-1-2-8-6(5-7)3-4-9-8/h1-2,5,9-10H,3-4H2

InChIKey

MPCXQPXCYDDJSR-UHFFFAOYSA-N

LogP

1.3601999999999999

Topological Polar Surface Area

32.26 Å²

Hydrogen Bond Donor/Acceptor

2 / 2

Complexity

126

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Synonyms & References

English

FT-0689941
SB66186
1H-Indol-5-ol,2,3-dihydro-
F15641
AKOS006279674
5-hydroxy-2,3-dihydro-1H-indole
5-Indolinol
MPCXQPXCYDDJSR-UHFFFAOYSA-N
2,3-dihydro-1 H-indol-5-ol
CS-W007244
5-hydroxyindoline
EN300-338952
AMY31798
PD180130
Indolin-5-ol
SCHEMBL59263
DTXSID40434426
2,3-dihydro-1H-indol-5-ol
2,3-Dihydroindol-5-ol;Indolin-5-ol
MFCD02181134
2,3-Dihydroindol-5-ol
A848130
1h-indol-5-ol,2,3-dihydro- hbr salt
DS-16441
SY111938
CHEMBL19331
BDBM50291681
172078-33-0
2,3-dihydro-1H-Indol-5-ol
2,3-DIHYDROINDOL-5-OL
1H-Indol-5-ol,2,3-dihydro

MDL Number

MFCD02181134

FAQ

What are the physical and chemical properties of 5-Indolinol (CAS: 172078-33-0)?

5-Indolinol is a colorless to light yellow liquid with a molecular weight of approximately 132.16 g/mol. It has a melting point of 28-29°C, boiling point of 227-229°C, and a density of 0.959 g/cm³. The compound is slightly soluble in water but miscible with most organic solvents. It is moderately reactive, showing basic properties due to the presence of an indoline ring.

How is 5-Indolinol (CAS: 172078-33-0) typically synthesized?

5-Indolinol is usually synthesized via the reaction of indole and methanol in the presence of concentrated sulfuric acid as a catalyst. The process involves condensation, followed by hydrogenation to introduce the alcohol functionality. The reaction is typically carried out at room temperature with a high yield of up to 90%. Other methods include the reduction of 2-(2-methoxyethyl)-1H-indole.

What industries use 5-Indolinol (CAS: 172078-33-0)?

5-Indolinol finds applications in the pharmaceutical industry as a precursor for the synthesis of certain drugs. It is also used in the development of polymers for medical and electronic applications. Additionally, it is used in sensor technology and as a component in the production of semiconductors due to its unique chemical properties.

What precautions should be taken when handling 5-Indolinol (CAS: 172078-33-0)?

When handling 5-Indolinol, wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Store the compound in a cool, dry place away from heat sources and oxidizers. Use a fume hood during manipulation to avoid inhalation of vapors. In case of a spill, neutralize with an alkali solution and dispose of the waste according to local regulations. Refer to the Safety Data Sheet (SDS) for detailed safety information.