5-Indolinol(CAS: 172078-33-0)

5-Indolinol is a colorless to light yellow liquid with a molecular weight of approximately 132.16 g/mol. It has a melting point of 28-29°C, boiling point of 227-229°C, and a density of 0.959 g/cm³. The compound is slightly soluble in water but miscible with most organic solvents. It is moderately reactive, showing basic properties due to the presence of an indoline ring.

5-Indolinol is usually synthesized via the reaction of indole and methanol in the presence of concentrated sulfuric acid as a catalyst. The process involves condensation, followed by hydrogenation to introduce the alcohol functionality. The reaction is typically carried out at room temperature with a high yield of up to 90%. Other methods include the reduction of 2-(2-methoxyethyl)-1H-indole.

5-Indolinol finds applications in the pharmaceutical industry as a precursor for the synthesis of certain drugs. It is also used in the development of polymers for medical and electronic applications. Additionally, it is used in sensor technology and as a component in the production of semiconductors due to its unique chemical properties.

When handling 5-Indolinol, wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Store the compound in a cool, dry place away from heat sources and oxidizers. Use a fume hood during manipulation to avoid inhalation of vapors. In case of a spill, neutralize with an alkali solution and dispose of the waste according to local regulations. Refer to the Safety Data Sheet (SDS) for detailed safety information.