1-Methyl-1H-indazol-4-ol

Basic Information

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CAS Number

144528-23-4

Molecular Formula

C8H8N2O

Molecular Weight

148.16 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Density

1.27±0.1 g/cm3 (20 ºC 760 Torr),

SMILES

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CN1C2=C(C=N1)C(=CC=C2)O

InChI

InChI=1S/C8H8N2O/c1-10-7-3-2-4-8(11)6(7)5-9-10/h2-5,11H,1H3

InChIKey

FMTRKWLCVGCOIB-UHFFFAOYSA-N

LogP

1.2788999999999997

Topological Polar Surface Area

38.05 Å²

Hydrogen Bond Donor/Acceptor

1 / 3

Complexity

151

Synonyms & References

English

1-methyl-1H-Indazol-4-ol
1-methyl-2H-indazol-4-one
1-methylindazol-4-ol
4-Hydroxy-1-methyl-1H-indazole
AG-C-03328
CTK8A0179
INDAZOL-4-OL, 1-METHYL-
SureCN1082224
MB10366
SY065458
144528-23-4
MFCD11869776
1H-Indazol-4-ol, 1-methyl-
FMTRKWLCVGCOIB-UHFFFAOYSA-N
AKOS023556850
SCHEMBL1082224
CS-0054264
DTXSID40441317
DB-191199
1-Methyl-1H-indazol-4-ol
W-205608
PS-4791

MDL Number

MFCD11869776

FAQ

What are the physical and chemical properties of 1-Methyl-1H-indazol-4-ol (CAS: 144528-23-4)?

1-Methyl-1H-indazol-4-ol is a crystalline solid with a molecular weight of approximately 168.21 g/mol. It has a low solubility in water but is more soluble in organic solvents like methanol and ethanol. It shows moderate reactivity in acidic conditions. The compound is stable under normal laboratory conditions but should be stored away from strong acids and bases.

How is 1-Methyl-1H-indazol-4-ol (CAS: 144523-4) typically synthesized?

1-Methyl-1H-indazol-4-ol can be synthesized via a multi-step process that involves the condensation of 1-methyl-1H-indazole with hydroxylamine hydrochloride. The reaction is typically performed under mild conditions, and the product can be isolated by recrystallization from ethanol. Catalysts such as sodium hydroxide may be used to enhance selectivity and yield.

What industries use 1-Methyl-1H-indazol-4-ol (CAS: 144528-23-4)?

1-Methyl-1H-indazol-4-ol is used in the pharmaceutical industry for the synthesis of certain drugs. It also has applications in the polymer industry, where it can act as a stabilizer or a functional group for further modification. Additionally, it can be utilized in sensor technologies and as a precursor in the semiconductor industry.

What precautions should be taken when handling 1-Methyl-1H-indazol-4-ol (CAS: 144528-23-4)?

When handling 1-Methyl-1H-indazol-4-ol, it is important to use personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. Work should be conducted in a well-ventilated area, preferably using a fume hood. Spills should be cleaned up using appropriate absorbent materials, and the area should be thoroughly rinsed. Always refer to the Safety Data Sheet (SDS) for detailed handling and emergency procedures.