1-Methyl-1H-indazol-4-ol(CAS: 144528-23-4)

1-Methyl-1H-indazol-4-ol is a crystalline solid with a molecular weight of approximately 168.21 g/mol. It has a low solubility in water but is more soluble in organic solvents like methanol and ethanol. It shows moderate reactivity in acidic conditions. The compound is stable under normal laboratory conditions but should be stored away from strong acids and bases.

1-Methyl-1H-indazol-4-ol can be synthesized via a multi-step process that involves the condensation of 1-methyl-1H-indazole with hydroxylamine hydrochloride. The reaction is typically performed under mild conditions, and the product can be isolated by recrystallization from ethanol. Catalysts such as sodium hydroxide may be used to enhance selectivity and yield.

1-Methyl-1H-indazol-4-ol is used in the pharmaceutical industry for the synthesis of certain drugs. It also has applications in the polymer industry, where it can act as a stabilizer or a functional group for further modification. Additionally, it can be utilized in sensor technologies and as a precursor in the semiconductor industry.

When handling 1-Methyl-1H-indazol-4-ol, it is important to use personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. Work should be conducted in a well-ventilated area, preferably using a fume hood. Spills should be cleaned up using appropriate absorbent materials, and the area should be thoroughly rinsed. Always refer to the Safety Data Sheet (SDS) for detailed handling and emergency procedures.