5-(3-Pyridinyl)-1H-indole

Basic Information

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CAS Number

144104-49-4

Molecular Formula

C13H10N2

Molecular Weight

194.24 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

SMILES

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C1=CC(=CN=C1)C2=CC3=C(C=C2)NC=C3

InChI

InChI=1S/C13H10N2/c1-2-12(9-14-6-1)10-3-4-13-11(8-10)5-7-15-13/h1-9,15H

InChIKey

KOUOYJYRICGOSC-UHFFFAOYSA-N

LogP

3.2299000000000015

Topological Polar Surface Area

28.68 Å²

Hydrogen Bond Donor/Acceptor

1 / 2

Complexity

217

Synonyms & References

English

AKOS006292395
5-(pyridin-3-yl)-1h-indole
MFCD04114730
A808173
5-(3-Pyridyl)-1H-indole
SCHEMBL6657347
CHEMBL1435857
144104-49-4
HMS3330H14
5-PYRIDIN-3-YL-1H-INDOLE
MLS002206296
1H-Indole, 5-(3-pyridinyl)-
AB18875
FT-0744278
A1-35155
5-Pridin-3-yl-1H-indole
SMR001295114
DTXSID90566327
HMS2210G03
CS-0334087
1H-Indole,5-(3-pyridinyl)-
5-(3-pyridinyl)-1H-indole
5-(3-pyridinyl)indole
5-(3-pyridyl)indole
5-(pyridin-3-yl)-1H-indole
ACMC-20n3m0
AGN-PC-0035TQ
SureCN6657347

MDL Number

MFCD04114730

Customs Code

2933990090

FAQ

What are the physical and chemical properties of 5-(3-Pyridinyl)-1H-indole (CAS: 144104-49-4)?

5-(3-Pyridinyl)-1H-indole is a crystalline compound with a molecular weight of approximately 213.2 g/mol. It has limited water solubility and is more soluble in organic solvents like ethanol and acetone. Chemically, it exhibits basic properties due to the indole ring and can undergo electrophilic aromatic substitution reactions easily.

How is 5-(3-Pyridinyl)-1H-indole (CAS: 144104-49-4) typically synthesized?

5-(3-Pyridinyl)-1H-indole is commonly synthesized via the reaction of pyridine with indole in the presence of a suitable catalyst, such as sodium hydroxide, in an aprotic solvent like dimethylformamide (DMF). The yield is typically around 70-80%, with good selectivity for the desired product.

What industries use 5-(3-Pyridinyl)-1H-indole (CAS: 144104-49-4)?

5-(3-Pyridinyl)-1H-indole finds applications in the pharmaceutical industry as an intermediate in the synthesis of various bioactive compounds. It is also used in the polymer industry for the development of functional materials and in sensor technology for its specific chemical reactivity.

What precautions should be taken when handling 5-(3-Pyridinyl)-1H-indole (CAS: 144104-49-4)?

When handling 5-(3-Pyridinyl)-1H-indole, it is crucial to use appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. Ensure the use of a fume hood during handling to minimize inhalation risks. Spills should be treated with caution; use absorbent materials and dispose of properly according to local regulations. Always consult the Safety Data Sheet (SDS) for detailed safety information.