5-(3-Pyridinyl)-1H-indole(CAS: 144104-49-4)

5-(3-Pyridinyl)-1H-indole is a crystalline compound with a molecular weight of approximately 213.2 g/mol. It has limited water solubility and is more soluble in organic solvents like ethanol and acetone. Chemically, it exhibits basic properties due to the indole ring and can undergo electrophilic aromatic substitution reactions easily.

5-(3-Pyridinyl)-1H-indole is commonly synthesized via the reaction of pyridine with indole in the presence of a suitable catalyst, such as sodium hydroxide, in an aprotic solvent like dimethylformamide (DMF). The yield is typically around 70-80%, with good selectivity for the desired product.

5-(3-Pyridinyl)-1H-indole finds applications in the pharmaceutical industry as an intermediate in the synthesis of various bioactive compounds. It is also used in the polymer industry for the development of functional materials and in sensor technology for its specific chemical reactivity.

When handling 5-(3-Pyridinyl)-1H-indole, it is crucial to use appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. Ensure the use of a fume hood during handling to minimize inhalation risks. Spills should be treated with caution; use absorbent materials and dispose of properly according to local regulations. Always consult the Safety Data Sheet (SDS) for detailed safety information.