4-Methoxy-N-phenylaniline

Basic Information

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CAS Number

1208-86-2

Molecular Formula

C13H13NO

Molecular Weight

199.25 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Physical Properties

Melting Point

104.0 to 108.0 deg-C

Boiling Point

195°C/12mmHg

Density

1.1100

Flash Point

134.1±12.6 °C

Refractive Index

1.61

Vapor Pressure

0.0±0.7 mmHg at 25°C

SMILES

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COC1=CC=C(C=C1)NC2=CC=CC=C2

InChI

InChI=1S/C13H13NO/c1-15-13-9-7-12(8-10-13)14-11-5-3-2-4-6-11/h2-10,14H,1H3

InChIKey

OBHGSIGHEBGGFS-UHFFFAOYSA-N

LogP

3.4388000000000014

Topological Polar Surface Area

21.259999999999998 Å²

Hydrogen Bond Donor/Acceptor

1 / 2

Complexity

169

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Synonyms & References

English

1208-86-2
FT-0655814
Oprea1_627634
4-methoxy-N-phenylaniline
NSC31630
4-methoxyphenylaniline
EINECS 214-902-9
DS-18561
AB01100227-03
NSC 31630
Benzenamine, 4-methoxy-N-phenyl-
4-methoxy-N-phenyl-aniline
NSC-31630
NS00023936
N-(4-Methoxyphenyl)-N-phenylamine
SY036318
SCHEMBL316390
N-(4-Methoxyphenyl)-N-phenylamine #
SR-01000393532
N-Phenyl-p-anisidine
(4-Methoxy-phenyl)-phenyl-amine
DTXSID70153017
Z56926525
AKOS001061312
MFCD00228649
M2069
J-501425
(4-methoxy-phenyl)-phenyl-amine, AldrichCPR
AMY17952
A804608
CS-W010506

MDL Number

MFCD00228649

Customs Code

2922299090

FAQ

What are the physical and chemical properties of 4-Methoxy-N-phenylaniline (CAS: 1208-86-2)?

4-Methoxy-N-phenylaniline (CAS: 1208-86-2) is a white crystalline solid with a molecular weight of approximately 194.21 g/mol. It has a melting point of 59-61°C and is slightly soluble in water. Chemically, it is less reactive than its parent compound but can undergo electrophilic aromatic substitution reactions. It is insoluble in most common organic solvents, making it useful for certain purification and synthesis steps.

How is 4-Methoxy-N-phenylaniline (CAS: 1208-86-2) typically synthesized?

4-Methoxy-N-phenylaniline is typically synthesized from p-aminophenol and methanol via a methylation reaction, often using a strong acid like sulfuric acid as a catalyst. The reaction selectively methylates the ortho-position, producing a high yield of 4-methoxy-N-phenylaniline. This method is efficient and widely used in the chemical industry.

What industries use 4-Methoxy-N-phenylaniline (CAS: 1208-86-2)?

4-Methoxy-N-phenylaniline (CAS: 1208-86-2) is primarily used in the pharmaceutical industry as a precursor for the synthesis of certain drugs. It is also utilized in the production of organic pigments, dyes, and other organic chemicals. Additionally, it finds applications in the development of sensors and semiconductors due to its chemical reactivity.

What precautions should be taken when handling 4-Methoxy-N-phenylaniline (CAS: 1208-86-2)?

When handling 4-Methoxy-N-phenylaniline (CAS: 1208-86-2), it is important to wear appropriate personal protective equipment (PPE), including gloves and safety goggles. Store it in a cool, dry place, away from heat and direct sunlight. In case of a spill, use appropriate absorbent materials and follow the safety data sheet (SDS) guidelines for disposal. Always work in a well-ventilated area or fume hood to minimize exposure to vapors.