4-Fluoro-2-methoxynicotinic acid

Basic Information

View in Editor

CAS Number

1060806-71-4

Molecular Formula

C7H6FNO3

Molecular Weight

171.13 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

Boiling Point

263.6±35.0 ºC (760 Torr),

Flash Point

113.2±25.9 ºC,

SMILES

View in Editor

COc1nccc(c1C(=O)O)F

InChI

InChI=1S/C7H6FNO3/c1-12-6-5(7(10)11)4(8)2-3-9-6/h2-3H,1H3,(H,10,11)

InChIKey

ORHZNDYRRYQHDK-UHFFFAOYSA-N

LogP

0.9275

Topological Polar Surface Area

59.42 Å²

Hydrogen Bond Donor/Acceptor

1 / 4

Complexity

176

Synonyms & References

English

4-FLUORO-2-METHOXYNICOTINIC ACID
4-Fluoro-2-methoxypyridine-3-carboxylic acid
AB67029
AK549307
4-Fluoro-2-methoxy-nicotinic acid

MDL Number

MFCD13188735

FAQ

What are the physical and chemical properties of 4-Fluoro-2-methoxynicotinic acid (CAS: 1060806-71-4)?

4-Fluoro-2-methoxynicotinic acid is a crystalline compound with a molecular weight of approximately 193.13 g/mol. It is slightly soluble in water and ethanol. The compound is reactive towards basic conditions and can undergo hydrolysis. It has a melting point of around 175-178°C and exhibits good stability in neutral and acidic media.

How is 4-Fluoro-2-methoxynicotinic acid (CAS: 1060806-71-4) typically synthesized?

4-Fluoro-2-methoxynicotinic acid is commonly synthesized by the reaction of 2-methoxynicotinic acid with hydrogen fluoride or by fluorination of 2-methoxynicotinic acid. The reaction involves heating the precursor in the presence of a suitable catalyst. The yield is typically around 70-80%, and the product is purified by recrystallization.

What industries use 4-Fluoro-2-methoxynicotinic acid (CAS: 1060806-71-4)?

4-Fluoro-2-methoxynicotinic acid is primarily used in the pharmaceutical industry as an intermediate in the synthesis of certain drugs. It is also used in the sensor industry for developing chemical sensors due to its specific reactivity. This compound can be found in applications related to polymer research and development as well.

What precautions should be taken when handling 4-Fluoro-2-methoxynicotinic acid (CAS: 1060806-71-4)?

Proper personal protective equipment (PPE) should be worn when handling 4-Fluoro-2-methoxynicotinic acid, including gloves and safety glasses. This compound should be handled in a fume hood to minimize inhalation risks. Spills should be cleaned up using absorbent material and the area should be thoroughly rinsed with water. Always refer to the Safety Data Sheet (SDS) for detailed handling and emergency procedures.