4-Fluoro-2-methoxynicotinic acid(CAS: 1060806-71-4)

4-Fluoro-2-methoxynicotinic acid is a crystalline compound with a molecular weight of approximately 193.13 g/mol. It is slightly soluble in water and ethanol. The compound is reactive towards basic conditions and can undergo hydrolysis. It has a melting point of around 175-178°C and exhibits good stability in neutral and acidic media.

4-Fluoro-2-methoxynicotinic acid is commonly synthesized by the reaction of 2-methoxynicotinic acid with hydrogen fluoride or by fluorination of 2-methoxynicotinic acid. The reaction involves heating the precursor in the presence of a suitable catalyst. The yield is typically around 70-80%, and the product is purified by recrystallization.

4-Fluoro-2-methoxynicotinic acid is primarily used in the pharmaceutical industry as an intermediate in the synthesis of certain drugs. It is also used in the sensor industry for developing chemical sensors due to its specific reactivity. This compound can be found in applications related to polymer research and development as well.

Proper personal protective equipment (PPE) should be worn when handling 4-Fluoro-2-methoxynicotinic acid, including gloves and safety glasses. This compound should be handled in a fume hood to minimize inhalation risks. Spills should be cleaned up using absorbent material and the area should be thoroughly rinsed with water. Always refer to the Safety Data Sheet (SDS) for detailed handling and emergency procedures.