4-Iodo-3-pyridinamine

Basic Information

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CAS Number

105752-11-2

Molecular Formula

C5H5IN2

Molecular Weight

220.01 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

65-70 °C

Boiling Point

327.2 °C at 760 mmHg

Flash Point

151.7 °C

Refractive Index

1.702

SMILES

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C1=CN=CC(=C1I)N

InChI

InChI=1S/C5H5IN2/c6-4-1-2-8-3-5(4)7/h1-3H,7H2

InChIKey

ZJRSKTXMSIVNAU-UHFFFAOYSA-N

LogP

1.2684000000000002

Topological Polar Surface Area

38.91 Å²

Hydrogen Bond Donor/Acceptor

2 / 2

Complexity

76.8

Safety Information

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GHS Hazard Pictograms

H302

H312

H332

H315

H319

H335

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H312 Harmful in contact with skin
Acute toxicity, dermal

H332 Harmful if inhaled
Acute toxicity, inhalation

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class IRRITANT Class IRRITANT

Sensitiveness

Air & Light Sensitive

Synonyms & References

English

BCP23200
MFCD04971334
ZJRSKTXMSIVNAU-UHFFFAOYSA-N
Q-103377
4-IODO-PYRIDIN-3-YLAMINE
SY027942
3-Amino-4-iodopyridine
AM20050636
SCHEMBL1427609
105752-11-2
3-Pyridinamine, 4-iodo-
CHEBI:132363
DTXSID80356052
EN300-233503
FT-0603740
CS-W007755
4-Iodopyridin-3-amine
PB23406
3-Amino-4-iodopyridine, 97%
AKOS005258947
3-AMINE-4-IODOPYRIDINE
4-iodo-3-aminopyridine
DS-11120
SB10507
AC-5154
4-IODO-3-AMINOPYRIDINE
3-amine-4-iodopyridin
3-amine-4-iodopyridine
4-iodopyridin-3-amine
4-Iodopyridin-3-ylamine
3-amino-4-iodo-pyridine

MDL Number

MFCD04971334

Customs Code

2933399090

FAQ

What are the physical and chemical properties of 4-Iodo-3-pyridinamine (CAS: 105752-11-2)?

4-Iodo-3-pyridinamine (CAS: 105752-11-2) is a crystalline solid with a molecular weight of approximately 227.04 g/mol. It is moderately soluble in water and ethanol. Chemically, it is reactive towards nucleophiles, particularly towards iodo groups, which can be readily replaced by other substituents. It has a relatively low vapor pressure and is stable under normal conditions.

How is 4-Iodo-3-pyridinamine (CAS: 105752-11-2) typically synthesized?

4-Iodo-3-pyridinamine can be synthesized via the reduction of 4-bromo-3-pyridinamine with sodium iodide in aqueous sodium hydroxide. The reaction is carried out at room temperature, and the iodine substitution is highly selective. Yield is typically around 85-90%, with good purity.

What industries use 4-Iodo-3-pyridinamine (CAS: 105752-11-2)?

4-Iodo-3-pyridinamine is primarily used in pharmaceutical research and development, particularly in the synthesis of certain drug candidates. It may also find applications in the development of novel materials for sensors and semiconductors due to its unique chemical properties.

What precautions should be taken when handling 4-Iodo-3-pyridinamine (CAS: 105752-11-2)?

When handling 4-Iodo-3-pyridinamine (CAS: 105752-11-2), ensure the use of personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Store in a cool, dry place away from direct sunlight. Work in a well-ventilated area or fume hood to minimize inhalation risks. Always refer to the Safety Data Sheet (SDS) for detailed handling instructions and emergency procedures.