4-Iodo-3-pyridinamine(CAS: 105752-11-2)

4-Iodo-3-pyridinamine (CAS: 105752-11-2) is a crystalline solid with a molecular weight of approximately 227.04 g/mol. It is moderately soluble in water and ethanol. Chemically, it is reactive towards nucleophiles, particularly towards iodo groups, which can be readily replaced by other substituents. It has a relatively low vapor pressure and is stable under normal conditions.

4-Iodo-3-pyridinamine can be synthesized via the reduction of 4-bromo-3-pyridinamine with sodium iodide in aqueous sodium hydroxide. The reaction is carried out at room temperature, and the iodine substitution is highly selective. Yield is typically around 85-90%, with good purity.

4-Iodo-3-pyridinamine is primarily used in pharmaceutical research and development, particularly in the synthesis of certain drug candidates. It may also find applications in the development of novel materials for sensors and semiconductors due to its unique chemical properties.

When handling 4-Iodo-3-pyridinamine (CAS: 105752-11-2), ensure the use of personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Store in a cool, dry place away from direct sunlight. Work in a well-ventilated area or fume hood to minimize inhalation risks. Always refer to the Safety Data Sheet (SDS) for detailed handling instructions and emergency procedures.