Compound Q&A

How is 4,4-Difluoro-1-methylpiperidine (CAS: 1186194-60-4) typically synthesized?

Answer

4,4-Difluoro-1-methylpiperidine
4,4-Difluoro-1-methylpiperidine is synthesized via the reaction of 1-methylpiperidine with hydrogen fluoride (HF) in the presence of potassium fluoride (KF) as a catalyst. The process yields high purity material with a high selectivity and good yield.

About

English Name 4,4-Difluoro-1-methylpiperidine
Molecular Formula C6H11F2N
Molecular Weight 135.16 g/mol
SMILES CN1CCC(CC1)(F)F
InChIKey LFHMKODCPPOLIB-UHFFFAOYSA-N
Last Updated: 2026-04-01 19:31

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