Compound Q&A
How is 1-(Chloromethyl)-2-fluoro-3-(trifluoromethoxy)benzene (CAS: 1373864-66-4) typically synthesized?
Answer
1-(Chloromethyl)-2-fluoro-3-(trifluoromethoxy)benzene is typically synthesized via a multi-step process involving the chloromethylation of 2-fluoro-3-(trifluoromethoxy)benzene followed by a substitution reaction. The synthesis often uses catalytic amounts of a Lewis acid like aluminum chloride and a chloromethylating agent. The reaction conditions are carefully controlled to ensure high selectivity and yield.
About
CAS No
1373864-66-4
English Name
1-(Chloromethyl)-2-fluoro-3-(trifluoromethoxy)benzene
Molecular Formula
C8H5ClF4O
Molecular Weight
228.57 g/mol
SMILES
c1cc(c(c(c1)OC(F)(F)F)F)CCl
InChIKey
RXMSLJKBPIQURI-UHFFFAOYSA-N
Last Updated: 2026-03-31 17:51
