Compound Q&A

What are the physical and chemical properties of 1-[(3S)-4-(7-[6-Amino-4-methyl-3-(trifluoromethyl)-2-pyridinyl]-6-chloro-8-fluoro-2-{[(2S)-1-methyl-2-pyrrolidinyl]methoxy}-4-quinazolinyl)-3-methyl-1-piperazinyl]-2-propen-1-one (CAS: 2417987-45-0)?

Answer

1-[(3S)-4-(7-[6-Amino-4-methyl-3-(trifluoromethyl)-2-pyridinyl]-6-chloro-8-fluoro-2-{[(2S)-1-methyl-2-pyrrolidinyl]methoxy}-4-quinazolinyl)-3-methyl-1-piperazinyl]-2-propen-1-one

This compound is a crystalline solid with a high molecular weight and low solubility in water. It is reactive and susceptible to hydrolysis under acidic conditions. It has a characteristic pKa of around 5.0 and a melting point of approximately 180°C.

About

CAS No 2417987-45-0

English Name 1-[(3S)-4-(7-[6-Amino-4-methyl-3-(trifluoromethyl)-2-pyridinyl]-6-chloro-8-fluoro-2-{[(2S)-1-methyl-2-pyrrolidinyl]methoxy}-4-quinazolinyl)-3-methyl-1-piperazinyl]-2-propen-1-one

Molecular Formula C29H32ClF4N7O2

Molecular Weight 622.06 g/mol

SMILES CN1CCC[C@H]1COC1=NC2=C(C=C(Cl)C(C3N=C(N)C=C(C)C=3C(F)(F)F)=C2F)C(=N1)N1CCN(C[C@@H]1C)C(=O)C=C

InChIKey ZRBPIAWWRPFDPY-IRXDYDNUSA-N

Last Updated: 2026-03-29 08:05

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