Compound Q&A
How is 2-(3,3,3-Trifluoropropyl)benzenesulfonamide (CAS: 94125-42-5) typically synthesized?
Answer
2-(3,3,3-Trifluoropropyl)benzenesulfonamide (CAS: 94125-42-5) is typically synthesized through a two-step process. First, 3,3,3-trifluoropropyl bromide is reacted with phenol to form the trifluoropropyl substituted phenol. Then, this intermediate undergoes sulfonation with concentrated sulfuric acid to produce the desired sulfonamide. The reaction is performed under anhydrous conditions, and the product is isolated by recrystallization or filtration, with high yield and selectivity.
About
CAS No
94125-42-5
English Name
2-(3,3,3-Trifluoropropyl)benzenesulfonamide
Molecular Formula
C9H10F3NO2S
Molecular Weight
253.24 g/mol
SMILES
C1=CC=C(C(=C1)CCC(F)(F)F)S(=O)(=O)N
InChIKey
PIJUMEVHGDAQBH-UHFFFAOYSA-N
Last Updated: 2026-03-28 19:11
