Compound Q&A
How is Methyl (6alpha,11beta,16alpha,17alpha)-6,9-difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylate (CAS: 28416-84-4) typically synthesized?
Answer
Methyl (6alpha,11beta,16alpha,17alpha)-6,9-difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylate (CAS: 28416-84-4) is typically synthesized via a multistep process involving the synthesis of the corresponding 17-carboxyandrostene, followed by the introduction of the fluoro substituents and the hydroxylation at C-11 and C-17 positions. The reaction often requires the use of specialized catalysts and reagents, with high chemical selectivity, and yields of around 75% can be achieved.
About
CAS No
28416-84-4
English Name
Methyl (6alpha,11beta,16alpha,17alpha)-6,9-difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylate
Molecular Formula
C22H28F2O5
Molecular Weight
410.46 g/mol
SMILES
COC(=O)[C@]2(O)[C@@]3(C)C[C@H](O)[C@]4(F)[C@@]\1(C)/C=C\C(=O)/C=C/1[C@@H](F)C[C@H]4[C@@H]3C[C@H]2C
InChIKey
HTJSTTZFHWMHDB-GQKYHHCASA-N
Last Updated: 2026-03-28 13:47
