Compound Q&A
How is (1S)-4-Methyl-1-[4-(trifluoromethyl)phenyl]-1-pentanamine (CAS: 869318-89-8) typically synthesized?
Answer
![(1S)-4-Methyl-1-[4-(trifluoromethyl)phenyl]-1-pentanamine](https://static.chemtradehub.com/structs/869/869318-89-8-c75c.webp "(1S)-4-Methyl-1-[4-(trifluoromethyl)phenyl]-1-pentanamine")
(1S)-4-Methyl-1-[4-(trifluoromethyl)phenyl]-1-pentanamine is typically synthesized via a multistep process involving the protection of a primary amine, introduction of a trifluoromethyl group, and subsequent deprotection. Commonly used reagents include trifluoromethyl chloroformate and protecting agents like tert-butyldimethylsilyl chloride. The overall yield is moderate, around 50-70%, and the method is selective towards the desired enantiomer with high enantioselectivity.
About
CAS No
869318-89-8
English Name
(1S)-4-Methyl-1-[4-(trifluoromethyl)phenyl]-1-pentanamine
Molecular Formula
C13H18F3N
Molecular Weight
245.29 g/mol
SMILES
CC(C)CC[C@@H](c1ccc(cc1)C(F)(F)F)N
InChIKey
UYCLWAPCXBUSGP-LBPRGKRZSA-N
Last Updated: 2026-03-28 13:47
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