How is (2S)-2-(3,4-Dimethoxyphenyl)-5,7-dimethoxy-2,3-dihydro-4H-chromen-4-one (CAS: 74628-43-6) typically synthesized?

This compound can be synthesized via a multistep reaction involving the protection of a phenolic hydroxyl group, followed by a condensation reaction to form the chromone skeleton. Common methods include the use of acetic anhydride for protection and the Birch reduction for the formation of the chromone. The reaction is typically conducted under anhydrous conditions with a yield of around 70-80%, and high selectivity towards the desired diastereoisomer.