How is 2-Methyl-2-propanyl (2S,5S)-5-(hydroxymethyl)-2-methyl-1-piperazinecarboxylate (CAS: 2375424-00-1) typically synthesized?

2-Methyl-2-propanyl (2S,5S)-5-(hydroxymethyl)-2-methyl-1-piperazinecarboxylate is usually synthesized via a multi-step process involving the protection of the primary amine, followed by reaction with a chloroacetic acid derivative, and subsequent deprotection. This process typically involves the use of protecting groups such as tert-butyldimethylsilyl (TBDMS), and the reaction is performed under mild acidic conditions. The overall yield is around 70-80%, with good regioselectivity and enantioselectivity.