Compound Q&A

How is 1-(4-methyloxazol-5-yl)ethan-1-one (CAS: 23012-19-3) typically synthesized?

Answer

1-(4-methyloxazol-5-yl)ethan-1-one
1-(4-methyloxazol-5-yl)ethan-1-one (CAS: 23012-19-3) can be synthesized via the condensation of 4-methyl-5-oxazolamine with acetaldehyde using a catalytic amount of a strong acid like hydrochloric acid. The reaction is carried out under reflux conditions. The use of other catalysts such as p-toluenesulfonic acid or sulfuric acid can also be effective. The yield of the reaction is around 70-80% with good selectivity.

About

CAS No 23012-19-3
English Name 1-(4-methyloxazol-5-yl)ethan-1-one
Molecular Formula C6H7NO2
Molecular Weight 125.13 g/mol
SMILES CC1=C(OC=N1)C(=O)C
InChIKey BYBRWPKBEPJABL-UHFFFAOYSA-N
Last Updated: 2026-03-22 14:59

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