Compound Q&A
How is N-(7-Chloro-1-{(3R)-1-[(2E)-4-(dimethylamino)-2-butenoyl]-3-azepanyl}-1H-benzimidazol-2-yl)-2-methylisonicotinamide methanesulfonate (CAS: 1508250-72-3) typically synthesized?
Answer
![N-(7-Chloro-1-{(3R)-1-[(2E)-4-(dimethylamino)-2-butenoyl]-3-azepanyl}-1H-benzimidazol-2-yl)-2-methylisonicotinamide methanesulfonate (1:1)](https://static.chemtradehub.com/structs/150/1508250-72-3-b5e2.webp "N-(7-Chloro-1-{(3R)-1-[(2E)-4-(dimethylamino)-2-butenoyl]-3-azepanyl}-1H-benzimidazol-2-yl)-2-methylisonicotinamide methanesulfonate (1:1)")
N-(7-Chloro-1-{(3R)-1-[(2E)-4-(dimethylamino)-2-butenoyl]-3-azepanyl}-1H-benzimidazol-2-yl)-2-methylisonicotinamide methanesulfonate (CAS: 1508250-72-3) is typically synthesized via the condensation of 7-chloro-1H-benzimidazol-2-ylamine with 2-methylisonicotinoyl chloride followed by methanesulfonation. The reaction is carried out under anhydrous conditions and requires a phase transfer catalyst. The yield is around 70-80% with high selectivity towards the desired product.
About
CAS No
1508250-72-3
English Name
N-(7-Chloro-1-{(3R)-1-[(2E)-4-(dimethylamino)-2-butenoyl]-3-azepanyl}-1H-benzimidazol-2-yl)-2-methylisonicotinamide methanesulfonate (1:1)
Molecular Formula
C27H35ClN6O5S
Molecular Weight
591.1340000000005 g/mol
SMILES
Cc1cc(ccn1)C(=O)Nc2nc3cccc(c3n2[C@@H]4CCCCN(C4)C(=O)/C=C/CN(C)C)Cl.CS(=O)(=O)O
InChIKey
BJRYTAMUVASSBY-ZJULCNDBSA-N
Last Updated: 2026-03-19 20:21
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