Compound Q&A
How is 1-Ethyl-1H-imidazole-4-carboxylic acid (CAS: 71925-07-0) typically synthesized?
Answer
1-Ethyl-1H-imidazole-4-carboxylic acid can be synthesized by the coupling of ethyl acetoacetate with 1H-imidazole in the presence of a base like sodium hydroxide. This reaction involves the nucleophilic substitution of the acetoacetate group by the amino group of imidazole. The yield can be improved by using a suitable solvent and ensuring proper mixing and temperature control.
About
CAS No
71925-07-0
English Name
1-Ethyl-1H-imidazole-4-carboxylic acid
Molecular Formula
C6H8N2O2
Molecular Weight
140.14 g/mol
SMILES
CCn1cnc(c1)C(=O)O
InChIKey
GWKQLHRGJVYPOJ-UHFFFAOYSA-N
Last Updated: 2026-03-17 06:03
