Compound Q&A

How is 1-(4-Biphenylyl)-3-(dimethylamino)-2-propen-1-one (CAS: 138716-22-0) typically synthesized?

Answer

1-(4-Biphenylyl)-3-(dimethylamino)-2-propen-1-one
1-(4-Biphenylyl)-3-(dimethylamino)-2-propen-1-one is commonly synthesized via a multistep process involving the reaction of 4-bromophenylboronic acid with dimethylaminopropargyl chloride followed by Suzuki coupling and subsequent ring closure. The process requires mild to moderate conditions and can achieve good yield with appropriate catalysts.

About

English Name 1-(4-Biphenylyl)-3-(dimethylamino)-2-propen-1-one
Molecular Formula C17H17NO
Molecular Weight 251.33 g/mol
SMILES CN(C)C=CC(=O)C1=CC=C(C=C1)C2=CC=CC=C2
InChIKey VOZCAYLHVNCRJS-UHFFFAOYSA-N
Last Updated: 2026-03-17 01:51

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