Compound Q&A

How is [3-Methyl-5-(trifluoromethyl)phenyl]boronic acid (CAS: 850411-13-1) typically synthesized?

Answer

[3-Methyl-5-(trifluoromethyl)phenyl]boronic acid
[3-Methyl-5-(trifluoromethyl)phenyl]boronic acid (CAS: 850411-13-1) is commonly synthesized via the Grignard reaction followed by the boronation of the phenolic ring. The process involves reacting a Grignard reagent with 3-methyl-5-(trifluoromethyl)benzaldehyde in an ether solvent, followed by treatment with boron tribromide or boron triiodide to generate the boronic acid derivative.

About

English Name [3-Methyl-5-(trifluoromethyl)phenyl]boronic acid
Molecular Formula C8H8BF3O2
Molecular Weight 203.956 g/mol
SMILES Cc1cc(cc(c1)C(F)(F)F)B(O)O
InChIKey ZZLZUGHSZSVQMK-UHFFFAOYSA-N
Last Updated: 2026-03-16 13:10

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