[3-Methyl-5-(trifluoromethyl)phenyl]boronic acid(CAS: 850411-13-1)

[3-Methyl-5-(trifluoromethyl)phenyl]boronic acid (CAS: 850411-13-1) is a crystalline solid with a molecular weight of approximately 308.07 g/mol. It is slightly soluble in water and more soluble in organic solvents like methanol and acetonitrile. This compound is known for its high reactivity, particularly in esterification and other organic reactions, making it a valuable reagent in synthetic chemistry.

[3-Methyl-5-(trifluoromethyl)phenyl]boronic acid (CAS: 850411-13-1) is commonly synthesized via the Grignard reaction followed by the boronation of the phenolic ring. The process involves reacting a Grignard reagent with 3-methyl-5-(trifluoromethyl)benzaldehyde in an ether solvent, followed by treatment with boron tribromide or boron triiodide to generate the boronic acid derivative.

[3-Methyl-5-(trifluoromethyl)phenyl]boronic acid (CAS: 850411-13-1) finds applications in the pharmaceutical industry for medicinal chemistry, as a precursor in the synthesis of complex molecules. It is also used in the polymer industry for the development of advanced materials, and in the semiconductor industry for the modification of electronic properties of materials.

When handling [3-Methyl-5-(trifluoromethyl)phenyl]boronic acid (CAS: 850411-13-1), it is essential to use personal protective equipment (PPE) such as gloves, goggles, and lab coats. The substance should be handled in a fume hood to minimize exposure to vapors. In case of a spill, it is recommended to use appropriate absorbent materials and dispose of them according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal information.