How is 2',3'-Dideoxy-3'-fluoroguanosine (CAS: 92562-88-4) typically synthesized?

2',3'-Dideoxy-3'-fluoroguanosine can be synthesized by modifying the structure of guanosine through a series of chemical reactions. Common methods involve the use of nucleoside chemistry, where the 2'- and 3'-hydroxyl groups are selectively removed, followed by introduction of a fluorine atom at the 3' position. This process typically requires careful control of reaction conditions to achieve high yields and selectivity.