Compound Q&A
How is Methyl 1H-imidazo[4,5-b]pyridine-7-carboxylate (CAS: 78316-09-3) typically synthesized?
Answer
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Methyl 1H-imidazo[4,5-b]pyridine-7-carboxylate can be synthesized through the reaction of 1H-imidazo[4,5-b]pyridine-7-carboxylic acid with methyl iodide in the presence of a base like sodium hydride. The reaction is typically performed in anhydrous tetrahydrofuran (THF) at room temperature. The yield is usually around 85%, and the product is isolated by recrystallization from ethanol.
About
CAS No
78316-09-3
English Name
Methyl 1H-imidazo[4,5-b]pyridine-7-carboxylate
Molecular Formula
C8H7N3O2
Molecular Weight
177.163 g/mol
SMILES
COC(=O)C1=C2C(=NC=C1)N=CN2
InChIKey
IEVPXSBGABKEOL-UHFFFAOYSA-N
Last Updated: 2026-03-10 23:59
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