Compound Q&A
How is 2-(Benzyloxy)-2-(2-naphthyl)acetonitrile (CAS: 500372-25-8) typically synthesized?
Answer
2-(Benzyloxy)-2-(2-naphthyl)acetonitrile is typically synthesized via a multi-step process involving the coupling of 2-benzyloxybenzonitrile with 2-naphthylboronic acid using Pd(PPh3)4 as a catalyst in the presence of a base like sodium carbonate. The reaction proceeds in a solvent like toluene or dioxane under microwave heating to enhance yield and selectivity. The final product is purified by recrystallization from ethanol.
About
CAS No
500372-25-8
English Name
2-(Benzyloxy)-2-(2-naphthyl)acetonitrile
Molecular Formula
C19H15NO
Molecular Weight
17.03 g/mol
SMILES
C1=CC=C(C=C1)COC(C#N)C2=CC3=CC=CC=C3C=C2
InChIKey
SLMXQIWKVZNVSR-UHFFFAOYSA-N
Last Updated: 2026-03-10 19:33
