Compound Q&A

How is 4-[(E)-(4-Carbamoylphenyl)diazenyl]-3-hydroxy-N-(2-methoxyphenyl)-2-naphthamide (CAS: 36968-27-1) typically synthesized?

Answer

4-[(E)-(4-Carbamoylphenyl)diazenyl]-3-hydroxy-N-(2-methoxyphenyl)-2-naphthamide
This compound is usually synthesized through a multi-step process involving diazotization, coupling, and amidation reactions. Commonly, a diazo compound derived from 4-carbamoylphenyl is combined with 2-naphthamide and a 2-methoxyphenyl group under basic conditions. The reaction typically uses sodium hydroxide or potassium hydroxide as a catalyst, with high selectivity and yield, making it a viable method for producing this compound in the laboratory.

About

CAS No 36968-27-1
English Name 4-[(E)-(4-Carbamoylphenyl)diazenyl]-3-hydroxy-N-(2-methoxyphenyl)-2-naphthamide
Molecular Formula C25H20N4O4
Molecular Weight 440.46 g/mol
SMILES COc4ccccc4NC(=O)c3cc1ccccc1c(/N=N/c2ccc(cc2)C(N)=O)c3O
InChIKey HULNYTPFPARJMG-ZQHSETAFSA-N
Last Updated: 2026-03-10 14:55

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