Compound Q&A
How is (5E)-5-(2-Hydroxy-3-methoxybenzylidene)-2-thioxo-1,3-thiazolidin-4-one (CAS: 99972-65-3) typically synthesized?
Answer
(5E)-5-(2-Hydroxy-3-methoxybenzylidene)-2-thioxo-1,3-thiazolidin-4-one is synthesized via a condensation reaction between a thiosemicarbazide and a substituted benzaldehyde, catalyzed by a Lewis acid. The reaction yields high purity and good selectivity, with a yield of up to 85%. This method provides a practical and efficient route to the synthesis of this important chemical intermediate.
About
CAS No
99972-65-3
English Name
(5E)-5-(2-Hydroxy-3-methoxybenzylidene)-2-thioxo-1,3-thiazolidin-4-one
Molecular Formula
C11H9NO3S2
Molecular Weight
267.33 g/mol
SMILES
COC1=CC=CC(=C1O)C=C2C(=O)NC(=S)S2
InChIKey
QRTIHKBCRWQQGK-VMPITWQZSA-N
Last Updated: 2026-03-10 14:55
