How is (2R,3R)-rel-1-(Dimethylamino)-3-(3-methoxyphenyl)-2-methylpentan-3-ol (CAS: 175590-76-8) typically synthesized?

(2R,3R)-rel-1-(Dimethylamino)-3-(3-methoxyphenyl)-2-methylpentan-3-ol is typically synthesized via a multistep process involving the formation of an intermediate ketone followed by reduction and alkylation reactions. The synthesis involves the use of a palladium catalyst and a base such as sodium tert-butoxide. High selectivity and yield are achieved through careful control of reaction conditions, such as temperature, solvent, and catalyst loading.