Compound Q&A
How is 1,2-Ethanediol, 1-(4-chloro-3-fluorophenyl)-, (1R)- (CAS: 1453854-84-6) typically synthesized?
Answer
1,2-Ethanediol, 1-(4-chloro-3-fluorophenyl)-, (1R)- (CAS: 1453854-84-6) is typically synthesized through a multistep process involving the protection of the hydroxyl group, alkylation, and subsequent deprotection. Commonly, this involves the use of acetyl protecting groups and various catalysts. The final step involves the resolution of the chiral center to obtain the (1R)-enantiomer with high selectivity and yield, often above 95%.
About
CAS No
1453854-84-6
English Name
1,2-Ethanediol, 1-(4-chloro-3-fluorophenyl)-, (1R)-
Molecular Formula
C8H8ClFO2
Molecular Weight
190.6 g/mol
SMILES
OC[C@@H](c1ccc(c(c1)F)Cl)O
InChIKey
ZNGGAPYUQROFJC-QMMMGPOBSA-N
Last Updated: 2026-03-08 00:27
