1,2-Ethanediol, 1-(4-chloro-3-fluorophenyl)-, (1R)-(CAS: 1453854-84-6)

The compound 1,2-Ethanediol, 1-(4-chloro-3-fluorophenyl)-, (1R)- (CAS: 1453854-84-6) is a crystalline solid with a molecular weight of approximately 228.57 g/mol. It has a low solubility in water (0.06 g/100 mL at 20°C) but is more soluble in organic solvents. The compound is relatively stable under normal conditions but can react with strong bases and acids. It is not flammable but may irritate the skin and eyes if exposed.

1,2-Ethanediol, 1-(4-chloro-3-fluorophenyl)-, (1R)- (CAS: 1453854-84-6) is typically synthesized through a multistep process involving the protection of the hydroxyl group, alkylation, and subsequent deprotection. Commonly, this involves the use of acetyl protecting groups and various catalysts. The final step involves the resolution of the chiral center to obtain the (1R)-enantiomer with high selectivity and yield, often above 95%.

1,2-Ethanediol, 1-(4-chloro-3-fluorophenyl)-, (1R)- (CAS: 1453854-84-6) is primarily used in pharmaceutical applications, where it serves as a building block for the synthesis of chiral compounds. It is also utilized in the production of certain polymers and as a reagent in sensor development and semiconductor manufacturing, although its specific applications may vary depending on the product formulation.

When handling 1,2-Ethanediol, 1-(4-chloro-3-fluorophenyl)-, (1R)- (CAS: 1453854-84-6), ensure the use of personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work in a well-ventilated area or a fume hood to minimize exposure. Spills should be cleaned up immediately using appropriate absorbents and should be handled in a manner that prevents skin contact. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal instructions.