Compound Q&A
How is (2R,3S)-2-{(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy}-3-(4-fluorophenyl)morpholine (CAS: 170729-79-0) typically synthesized?
Answer
![(2R,3S)-2-{(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy}-3-(4-fluorophenyl)morpholine](https://static.chemtradehub.com/structs/170/170729-79-0-0662.webp "(2R,3S)-2-{(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy}-3-(4-fluorophenyl)morpholine")
The compound is synthesized via a multi-step process involving alkylation and coupling reactions. Key steps include the formation of the morpholine ring, introduction of the fluorophenyl group, and installation of the 3,5-bis(trifluoromethyl)phenyl ethoxy substituent. Common catalysts include Pd complexes, and the overall yield is around 60-70%.
About
CAS No
170729-79-0
English Name
(2R,3S)-2-{(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy}-3-(4-fluorophenyl)morpholine
Molecular Formula
C20H18F7NO2
Molecular Weight
437.36 g/mol
SMILES
CC(C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)OC2C(NCCO2)C3=CC=C(C=C3)F
InChIKey
AFBDSAJOMZYQAI-CNOZUTPLSA-N
Last Updated: 2026-03-07 19:49
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