Compound Q&A

How is 4-(imidazol-1-ylmethyl)benzonitrile (CAS: 112809-54-8) typically synthesized?

Answer

4-(imidazol-1-ylmethyl)benzonitrile
4-(imidazol-1-ylmethyl)benzonitrile is typically synthesized by the reaction of 4-bromoaniline with imidazole in the presence of a base such as potassium carbonate or lithium hydroxide. The reaction involves a nucleophilic substitution followed by a condensation step. The yield can be improved by using a phase-transfer catalyst like tetrabutylammonium hydroxide and performing the reaction under reflux conditions.

About

English Name 4-(imidazol-1-ylmethyl)benzonitrile
Molecular Formula C11H9N3
Molecular Weight 17.03 g/mol
SMILES C1=CC(=CC=C1CN2C=CN=C2)C#N
InChIKey LUSFCTSUDCCYLQ-UHFFFAOYSA-N
Last Updated: 2026-03-05 12:33

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