Compound Q&A
How is 4-Morpholinyl(4-nitrophenyl)methanone (CAS: 5397-76-2) typically synthesized?
Answer
4-Morpholinyl(4-nitrophenyl)methanone is typically synthesized via the coupling of 4-nitrobenzaldehyde and morpholine in the presence of a base such as sodium hydroxide or potassium carbonate. The reaction is conducted in polar aprotic solvents like dimethylformamide (DMF) or N,N-dimethylacetamide (DMAc) at elevated temperatures, often around 80-90°C. The yield can be up to 85% with good selectivity.
About
CAS No
5397-76-2
English Name
4-Morpholinyl(4-nitrophenyl)methanone
Molecular Formula
C11H12N2O4
Molecular Weight
236.22 g/mol
SMILES
C1COCCN1C(=O)C2=CC=C(C=C2)[N+](=O)[O-]
InChIKey
VGGZQWDRWOXJTA-UHFFFAOYSA-N
Last Updated: 2026-03-05 06:57
