4-Morpholinyl(4-nitrophenyl)methanone(CAS: 5397-76-2)

4-Morpholinyl(4-nitrophenyl)methanone has a crystalline form with a molecular weight of approximately 286.14 g/mol. It is sparingly soluble in water but soluble in ethanol and methanol. Chemically, it is relatively stable but can undergo nitro reduction reactions under certain conditions. It is an important intermediate in organic synthesis, often used in reactions involving nucleophilic substitution and condensation.

4-Morpholinyl(4-nitrophenyl)methanone is typically synthesized via the coupling of 4-nitrobenzaldehyde and morpholine in the presence of a base such as sodium hydroxide or potassium carbonate. The reaction is conducted in polar aprotic solvents like dimethylformamide (DMF) or N,N-dimethylacetamide (DMAc) at elevated temperatures, often around 80-90°C. The yield can be up to 85% with good selectivity.

4-Morpholinyl(4-nitrophenyl)methanone is used in various industries, including pharmaceuticals, where it serves as a precursor to medicinal compounds. It is also utilized in the production of polymers and as a reagent in sensor and semiconductor applications due to its unique chemical properties and reactivity.

When handling 4-Morpholinyl(4-nitrophenyl)methanone, it is essential to use personal protective equipment (PPE) such as gloves and goggles to protect against skin and eye contact. Work should be conducted in a fume hood due to its volatile nature. Spills should be cleaned up immediately using a compatible absorbent material, and the area should be thoroughly ventilated. Always refer to the Safety Data Sheet (SDS) for detailed safety information and emergency procedures.