Compound Q&A
How is 3',5'-Bis-O-(4-chlorobenzoyl)-2'-deoxy-5-ethyluridine (CAS: 25137-84-2) typically synthesized?
Answer
3',5'-Bis-O-(4-chlorobenzoyl)-2'-deoxy-5-ethyluridine is typically synthesized via a multi-step process involving the phosphorylation of 5-ethyluridine followed by the benzoylation of the 3' and 5' positions using 4-chlorobenzoyl chloride. The reaction is catalyzed by a Lewis acid such as aluminum chloride and proceeds with good selectivity and yield. The product is then purified by recrystallization from suitable solvents.
About
CAS No
25137-84-2
English Name
3',5'-Bis-O-(4-chlorobenzoyl)-2'-deoxy-5-ethyluridine
Molecular Formula
C25H22Cl2N2O7
Molecular Weight
533.36 g/mol
SMILES
CCC1=CN(C(=O)NC1=O)C2CC(C(O2)COC(=O)C3=CC=C(C=C3)Cl)OC(=O)C4=CC=C(C=C4)Cl
InChIKey
NPKMNEQELHMKIT-PWRODBHTSA-N
Last Updated: 2026-03-05 06:57
