3',5'-Bis-O-(4-chlorobenzoyl)-2'-deoxy-5-ethyluridine(CAS: 25137-84-2)

3',5'-Bis-O-(4-chlorobenzoyl)-2'-deoxy-5-ethyluridine has a crystalline form and a molecular weight of approximately 538.23 g/mol. It is poorly soluble in water but soluble in common organic solvents like DMSO and DMF. The compound is quite reactive towards nucleophilic substitution and has a moderate tendency to undergo hydrolysis under basic conditions. It is stable under acidic conditions and in the solid state.

3',5'-Bis-O-(4-chlorobenzoyl)-2'-deoxy-5-ethyluridine is typically synthesized via a multi-step process involving the phosphorylation of 5-ethyluridine followed by the benzoylation of the 3' and 5' positions using 4-chlorobenzoyl chloride. The reaction is catalyzed by a Lewis acid such as aluminum chloride and proceeds with good selectivity and yield. The product is then purified by recrystallization from suitable solvents.

3',5'-Bis-O-(4-chlorobenzoyl)-2'-deoxy-5-ethyluridine is primarily used in the pharmaceutical industry for the development of novel drug candidates. It also finds applications in the chemical and sensor industries for the synthesis of specific compounds and in the development of advanced sensor technologies. In semiconductors, it can be used as a precursor in the manufacturing of certain materials.

When handling 3',5'-Bis-O-(4-chlorobenzoyl)-2'-deoxy-5-ethyluridine, it is essential to wear personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The substance should be stored in a cool, dry place away from heat and direct sunlight. Handling should be performed in a fume hood to minimize exposure to vapors. In case of a spill, the area should be ventilated and the spill cleaned up carefully with appropriate absorption materials. Always refer to the Safety Data Sheet (SDS) for specific handling and environmental disposal guidelines.