Compound Q&A
How is (1R,4R,5R)-2-Azabicyclo[2.2.1]heptane-2-carboxylic acid, 5-hydroxy-, 1,1-dimethylethyl ester (CAS: 198835-07-3) typically synthesized?
Answer
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(1R,4R,5R)-2-Azabicyclo[2.2.1]heptane-2-carboxylic acid, 5-hydroxy-, 1,1-dimethylethyl ester can be synthesized via a multi-step process starting from 2-azabicyclo[2.2.1]heptane-2-carboxylic acid. Typically, it involves esterification of the acid with 1,1-dimethylethanol in the presence of a catalytic amount of an acid such as hydrochloric acid. The reaction is carried out in an organic solvent like dichloromethane under reflux conditions, followed by purification through recrystallization.
About
CAS No
198835-07-3
English Name
2-Azabicyclo[2.2.1]heptane-2-carboxylic acid, 5-hydroxy-, 1,1-dimethylethyl ester, (1R,4R,5R)-rel-
Molecular Formula
C11H19NO3
Molecular Weight
213.2735 g/mol
SMILES
O[C@@H]1C[C@H]2C[C@@H]1CN2C(=O)OC(C)(C)C
InChIKey
HDPGSWMTDGGUEB-IWSPIJDZSA-N
Last Updated: 2026-03-05 06:57
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