Compound Q&A
How is 8-Chloro-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole (CAS: 19685-84-8) typically synthesized?
Answer
![8-Chloro-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole](https://static.chemtradehub.com/structs/196/19685-84-8-6fa2.webp "8-Chloro-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole")
8-Chloro-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole is usually synthesized through a multi-step process involving the coupling of 8-chloroquinoline with an aldehyde in the presence of a base like sodium hydride. The reaction proceeds via an organometallic intermediate, followed by a ring-closure step to form the indole ring. The overall yield is typically around 60-70%.
About
CAS No
19685-84-8
English Name
8-Chloro-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole
Molecular Formula
C11H11ClN2
Molecular Weight
206.68 g/mol
SMILES
C1CNCC2=C1NC3=C2C=C(C=C3)Cl
InChIKey
LCKUBQBEDRQTRC-UHFFFAOYSA-N
Last Updated: 2026-03-05 02:11
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